Clue : A rare, benign tumor of the adrenal medulla that causes excessive secretion of catecholamines leading to severe hypertension, headaches, palpitations, and intense sweating.

Clue : A tumor outside the pituitary gland that produces excessive hormone causing high cortisol levels, severe hypercortisolism, skin hyperpigmentation, high blood pressure, and muscle weakness.

Clue : A genetic disorder associated with decreased reaction of body tissues to thyroid hormones.

Clue : A highly aggressive central nervous system tumor that often presents with headache, vomiting, seizures, ataxia, and cranial nerve palsies.

Clue : A genetic, neuromuscular disorder that causes progressive degeneration resulting in muscle weakness, atrophy, and difficulty with movement, swallowing, and breathing.

Clue : An inherited neurodegenerative disorder leading to DNA repair failure. Progressive walking difficulties, balance issues, and dilated blood vessels in eyes/skin are early childhood symptoms.

Clue : A rare genetic condition combining urinary incontinence, kidney damage, and an inverted facial expression where smiling appears as crying.

Clue : A potentially life-threatening infection involving gas-forming bacteria within the bladder wall, occurring in diabetic, elderly females and presenting with abdominal pain, fever, and dysuria.

Clue : A condition considered one of the most severe birth defects, causing protruding internal organs, a non-fused pelvis, major spinal abnormalities, a shortened colon, and an imperforate anus.